HEMATOPOIESIS AND STEM CELLS Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor- on Fanconi anemia hematopoietic stem and progenitor cells
نویسندگان
چکیده
1Division of Hematology/Oncology Children’s Hospital Boston and Harvard Stem Cell Institute, MA; 2Department of Experimental Hematology, Hannover Medical School, Hannover, Germany; 3Division of Experimental Hematology and 4Center for Epidemiology and Biostatistics, Cincinnati Children’s Hospital Medical Center, OH; and 5Gene Therapy Group, Cancer Research United Kingdom Paterson Institute for Cancer Research, Manchester, United Kingdom
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Inflammatory ROS promote and cooperate with the Fanconi anemia mutation for hematopoietic senescence.
The proinflammatory cytokine tumor necrosis factor alpha (TNFalpha) inhibits hematopoietic stem cell (HSC) expansion, interferes with HSC self-renewal and compromises the ability of HSC to reconstitute hematopoiesis. We have investigated mechanisms by which TNFalpha suppresses hematopoiesis using the genomic instability syndrome Fanconi anemia mouse model deficient for the complementation-group...
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